Rheumatoid arthritis

Relevant risk variants from the literature

---

Population: Males of European ancestry

Locus	Chromo- some	Variant / SNP	My Codes	Relative Risk	Genotype frequency	Num. Cases / Num. Controls
HLA-DRB1	6	rs660895	AA	0.42	62.4%	1522 / 1850
Plenge, RM et al. N Engl J Med. 2007 Sep 20;357(12):1199-209. Epub 2007 Sep 5.
IL2 / IL21	4	rs6822844	GT	0.80	30.2%	1047 / 929
Zhernakova, A et al. Am J Hum Genet. 2007 Dec;81(6):1284-8. Epub 2007 Oct 24.
PTPN22	1	rs2476601	AG	1.48	16.1%	475 / 475
Begovich, AB et al. Am J Hum Genet. 2004 Aug;75(2):330-7. Epub 2004 Jun 18.
RA_6q23	6	rs2327832 rs13192841	AA AG	0.80	27.9%	2680 / 4469
Plenge, RM et al. Nat Genet. 2007 Dec;39(12):1477-82. Epub 2007 Nov 4.
STAT4	2	rs7574865	GG	0.87	60.8%	1620 / 2635
Remmers, EF et al. N Engl J Med. 2007 Sep 6;357(10):977-86.
TRAF1-C5 locus	9	rs3761847	AG	1.03	48.4%	1522 / 1850
Plenge, RM et al. N Engl J Med. 2007 Sep 20;357(12):1199-209. Epub 2007 Sep 5.

Chromosome location of relevant variants

---

The figure below shows the genomic location of the relevant variants, represented as stripes across the chromosome. Their color indicates your relative risk (red: high risk, yellow: medium risk, green: low risk). Hover over the variants with the mouse cursor to obtain more detailed information.

Keep in mind

---

These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease. Read more about how deCODEme calculates risks.

This test was developed and its performance characteristics determined by the deCODE genetics Diagnostic Laboratory. It has not been cleared or approved by the U. S. Food and Drug Administration (FDA).

Change history

---