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Recent changes:
Jan 04 2012, 11:35 AM Added seven variants for Europeans and one for East Asians
Nov 24 2009, 02:40 PM The publication for lifetime risk has been changed. Values used for the risk model have been modified accordingly
Nov 24 2009, 02:40 PM Added one risk variant for new customers of European descent

Heart attack


These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease.

How deCODEme calculates genetic risk

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Relevant risk variants from the literature

Population: Males of European ancestry
Locus Chromo-
some		 Variant / SNP My Codes Relative
Risk		 Genotype
frequency		 Num. Cases / Num. Controls
ADAMTS7 15 rs11072806 N/A 50258 / 91304
Schunkert, H et al. Nat Genet. 2011 Mar 6;43(4):333-8.
CDKN2A / CDKN2B 9 rs10757278 AG 0.98 49.9% 4587 / 12767
Helgadottir, A et al. Science. 2007 Jun 8;316(5830):1491-3. Epub 2007 May 3.
CELSR2 / PSRC1 1 rs599839 AG 0.86 35.4% 2875 / 4644
Samani, NJ et al. N Engl J Med. 2007 Aug 2;357(5):443-53. Epub 2007 Jul 18.
COL4A1-COL4A2 13 rs4773144 N/A 50258 / 91304
Schunkert, H et al. Nat Genet. 2011 Mar 6;43(4):333-8.
CXCL12 10 rs1746048 CC 1.05 70.6% 12544 / 44118
Kathiresan, S et al. Nat Genet. 2009 Mar;41(3):334-41. Epub 2009 Feb 8.
HHIPL1 14 rs12436072 N/A 50258 / 91304
Schunkert, H et al. Nat Genet. 2011 Mar 6;43(4):333-8.
LIPA 10 rs1412444 N/A 25000 / 22000
C4D Consortium. Nat Genet. 2011 Mar 6;43(4):339-44.
MIA3 1 rs2291834 CC 1.07 51.8% 12544 / 44118
Kathiresan, S et al. Nat Genet. 2009 Mar;41(3):334-41. Epub 2009 Feb 8.
MRAS 3 rs9818870 CC 0.96 71.6% 19407 / 21366
Erdmann, J et al. Nat Genet. 2009 Mar;41(3):280-2. Epub 2009 Feb 8.
PDGFD 11 rs974819 N/A 25000 / 22000
C4D Consortium. Nat Genet. 2011 Mar 6;43(4):339-44.
PHACTR1 6 rs7739181 GG 1.08 42.2% 12544 / 44118
Kathiresan, S et al. Nat Genet. 2009 Mar;41(3):334-41. Epub 2009 Feb 8.
RASD1-SMCR3-PEMT 17 rs12936587 N/A 50258 / 91304
Schunkert, H et al. Nat Genet. 2011 Mar 6;43(4):333-8.
SH2B3 12 rs3184504 CC 0.89 30.2% 6650 / 40621
Gudbjartsson DF, et al. Nat Genet. 2009 Feb 8. [Epub ahead of print]
SLC5A3 / MRPS6 / KCNE2 21 rs9982601 CT 1.14 22.6% 12544 / 44118
Kathiresan, S et al. Nat Genet. 2009 Mar;41(3):334-41. Epub 2009 Feb 8.
WDR12 2 rs6725887 TT 0.95 74.0% 12544 / 44118
Kathiresan, S et al. Nat Genet. 2009 Mar;41(3):334-41. Epub 2009 Feb 8.
ZC3HC1 7 rs11556924 N/A 50258 / 91304
Schunkert, H et al. Nat Genet. 2011 Mar 6;43(4):333-8.

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Chromosome location of relevant variants

The figure below shows the genomic location of the relevant variants, represented as stripes across the chromosome. Their color indicates your relative risk (red: high risk, yellow: medium risk, green: low risk). Hover over the variants with the mouse cursor to obtain more detailed information.

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Keep in mind

These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease. Read more about how deCODEme calculates risks.

This test was developed and its performance characteristics determined by the deCODE genetics Diagnostic Laboratory. It has not been cleared or approved by the U. S. Food and Drug Administration (FDA).