Crohn's disease

Relevant risk variants from the literature

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Population: Males of European ancestry

Locus	Chromo- some	Variant / SNP	My Codes	Relative Risk	Genotype frequency	Num. Cases / Num. Controls
10p11	10	rs4934724	CT	1.04	45.2%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
10q21	10	rs224136	CC	1.19	62.4%	1826 / 1714
Rioux, JD et al. Nat Genet. 2007 May;39(5):596-604. Epub 2007 Apr 15.
13q14	13	rs3764147	AA	0.90	60.7%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
1q24	1	rs9286879	AA	0.91	57.3%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
21q21	21	rs1736148	CC	0.82	18.9%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
5p13	5	rs17234657	TT	0.96	75.3%	1182 / 2024
Parkes, M et al. Nat Genet. 2007 Jul;39(7):830-2. Epub 2007 Jun 6.
6q21	6	rs7746082	Missing data			5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
7p12	7	rs1456893	AG	0.93	43.7%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
8q24	8	rs1551398	TT	1.06	38.3%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
ATG16L1	2	rs2241880	CC	1.37	28.1%	2500 / 2800
Hampe, J et al. Nat Genet. 2007 Feb;39(2):207-11. Epub 2006 Dec 31.
BSN	3	rs9858542	AG	1.06	41.3%	1182 / 2024
Parkes, M et al. Nat Genet. 2007 Jul;39(7):830-2. Epub 2007 Jun 6.
CCR6	6	rs2301436	AG	1.01	49.7%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
CDKAL1	6	rs6908425	CC	1.08	60.8%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
IBD5	5	rs12521868	GT	1.01	49.5%	1283 / 1012
Silverberg, MS et al. Eur J Hum Genet. 2007 Mar;15(3):328-35. Epub 2007 Jan 10.
ICISLG	21	rs762421	GG	1.16	15.1%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
IL12B	5	rs10045431	CC	1.06	50.1%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
IL23R	1	rs10889677 rs11209026	CC GG	0.83	39.7%	948 / 981
Duerr, RH et al. Science. 2006 Dec 1;314(5804):1461-3. Epub 2006 Oct 26.
IRGM	5	rs4958847	GG	0.92	77.4%	1182 / 2024
Parkes, M et al. Nat Genet. 2007 Jul;39(7):830-2. Epub 2007 Jun 6.
ITLN1	1	rs2274910	CC	1.08	46.5%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
JAK2	9	rs10758669	CC	1.16	12.1%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
KIF21B	1	rs12122721	AG	0.93	42.2%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
NELL1	11	rs1519717 rs1793000	TT TT	1.11	51.7%	2394 / 1481
Franke, A et al. PLoS ONE. 2007 Aug 8;2(1):e691.
NKX2-3	10	rs11190140	CT	1.00	49.9%	1182 / 2024
Parkes, M et al. Nat Genet. 2007 Jul;39(7):830-2. Epub 2007 Jun 6.
NOD2	16	rs2066843	CC	0.83	50.8%	1742 / 3000
WTCCC. Nature. 2007 Jun 7;447(7145):661-78.
ORMDL3	17	rs2872507	GG	0.90	27.8%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
PTPN22	1	rs6679677	AC	0.80	18.2%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
PTPN2	18	rs2542151	TT	0.90	71.9%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
STAT3	17	rs744166	CT	0.97	49.2%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
TNFSF15	9	rs4263839	GG	1.13	45.8%	5555 / 6638
Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.

Chromosome location of relevant variants

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The figure below shows the genomic location of the relevant variants, represented as stripes across the chromosome. Their color indicates your relative risk (red: high risk, yellow: medium risk, green: low risk). Hover over the variants with the mouse cursor to obtain more detailed information.

Keep in mind

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These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease. Read more about how deCODEme calculates risks.

This test was developed and its performance characteristics determined by the deCODE genetics Diagnostic Laboratory. It has not been cleared or approved by the U. S. Food and Drug Administration (FDA).

Change history

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