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Colorectal cancer


These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease.

How deCODEme calculates genetic risk

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Relevant risk variants from the literature

Population: Males of European ancestry
Locus Chromo-
some		 Variant / SNP My Codes Relative
Risk		 Genotype
frequency		 Num. Cases / Num. Controls
10p14 10 rs10795668 GG 1.07 44.9% 17940 / 17940
Tomlinson, IP M et al. Nat Genet. 2008 May;40(5):623-30. Epub 2008 Mar 30.
11q23 11 rs3802842 AA 0.94 50.4% 13057 / 13174
Tenesa, A et al. Nat Genet. 2008 May;40(5):631-7. Epub 2008 Mar 30.
20p12 20 rs961253 CC 0.92 41.0% 20186 / 20855
Houlston, RS et al. Nat Genet. 2008 Dec;40(12):1426-35. Epub 2008 Nov 16.
BMP4 14 rs4444235 CC 1.12 21.2% 20186 / 20855
Houlston, RS et al. Nat Genet. 2008 Dec;40(12):1426-35. Epub 2008 Nov 16.
CRAC1 15 rs4779584 CC 0.91 67.2% 7922 / 6741
Jaeger, E et al. Nat Genet. 2008 Jan;40(1):26-8. Epub 2007 Dec 16.
EIF3H 8 rs16892766 AA 0.97 86.5% 18431 / 17940
Tomlinson, IP M et al. Nat Genet. 2008 May;40(5):623-30. Epub 2008 Mar 30.
POU5F1P1 8 rs6983267 GT 0.99 50.0% 8000 / 6800
Tomlinson, I et al. Nat Genet. 2007 Aug;39(8):984-8. Epub 2007 Jul 8.
SMAD7 18 rs4939827 TT 1.16 27.0% 8000 / 6800
Broderick, P et al. Nat Genet. 2007 Nov;39(11):1315-7. Epub 2007 Oct 14.

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Chromosome location of relevant variants

The figure below shows the genomic location of the relevant variants, represented as stripes across the chromosome. Their color indicates your relative risk (red: high risk, yellow: medium risk, green: low risk). Hover over the variants with the mouse cursor to obtain more detailed information.

Crc

Keep in mind

These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease. Read more about how deCODEme calculates risks.

This test was developed and its performance characteristics determined by the deCODE genetics Diagnostic Laboratory. It has not been cleared or approved by the U. S. Food and Drug Administration (FDA).

Change history

Date Change
Feb 23 2009, 11:14 AM Added two new risk variants for Europeans
Apr 30 2008, 03:48 PM Updated risk estimation for variant rs4939827.
Apr 30 2008, 03:48 PM Added three risk variants for Europeans and two for East Asians.