Chronic lymphocytic leukemia

Relevant risk variants from the literature

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Population: Males of European ancestry

Locus	Chromo- some	Variant / SNP	My Codes	Relative Risk	Genotype frequency	Num. Cases / Num. Controls
15q23	15	rs7176508	AG	1.06	46.6%	1529 / 3115
Di Bernardo, MC et al. Nat Genet. 2008 Oct;40(10):1204-10. Epub 2008 Aug 31.
8q24	8	rs2456449	GG	1.33	13.0%	2503 / 5789
Crowther-Swanepoel D, et al. Nat Genet. 2010 Jan 10.
ACOXL / BCL2L11	2	rs17483466	AA	0.86	64.0%	1529 / 3115
Di Bernardo, MC et al. Nat Genet. 2008 Oct;40(10):1204-10. Epub 2008 Aug 31.
FARP2	2	rs757978	AG	1.29	18.0%	2503 / 5789
Crowther-Swanepoel D, et al. Nat Genet. 2010 Jan 10.
GRAMD1B	11	rs735665	AG	1.21	33.2%	1529 / 3115
Di Bernardo, MC et al. Nat Genet. 2008 Oct;40(10):1204-10. Epub 2008 Aug 31.
IRF4	6	rs872071	AA	0.60	21.2%	1529 / 3116
Di Bernardo, MC et al. Nat Genet. 2008 Oct;40(10):1204-10. Epub 2008 Aug 31.
PRKD2 / STRN4	19	rs11083846	GG	0.86	60.8%	1529 / 3115
Di Bernardo, MC et al. Nat Genet. 2008 Oct;40(10):1204-10. Epub 2008 Aug 31.
SP140 / SP110	2	rs13397985	TT	0.86	65.6%	1529 / 3115
Di Bernardo, MC et al. Nat Genet. 2008 Oct;40(10):1204-10. Epub 2008 Aug 31.

Chromosome location of relevant variants

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The figure below shows the genomic location of the relevant variants, represented as stripes across the chromosome. Their color indicates your relative risk (red: high risk, yellow: medium risk, green: low risk). Hover over the variants with the mouse cursor to obtain more detailed information.

Keep in mind

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These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease. Read more about how deCODEme calculates risks.

This test was developed and its performance characteristics determined by the deCODE genetics Diagnostic Laboratory. It has not been cleared or approved by the U. S. Food and Drug Administration (FDA).

Change history

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