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This report is for females of European ancestry, which does not match your settings for males of European ancestry. The results may therefore not be applicable for you.

Recent changes:
Dec 22 2011, 11:45 AM Added one variant for Europeans and one variant for East Asians
Mar 28 2011, 09:36 AM Added four risk variants for individuals of European descent and one variant for African Americans
Oct 29 2009, 10:50 AM Added one risk variant for Europeans

Breast cancer


These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease.

How deCODEme calculates genetic risk

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Relevant risk variants from the literature

Population: Females of European ancestry
Locus Chromo-
some		 Variant / SNP My Codes Relative
Risk		 Genotype
frequency		 Num. Cases / Num. Controls
11q13 11 rs614367 CC 0.96 72.2% 12114 / 11967
Turnbull, Clare et al. Nat Genet. 2010 Jun;42(6):504-7. Epub 2010 May 9.
1p11 1 rs11249433 TT 0.89 37.2% 9335 / 10263
Thomas, G et al. Nat Genet. 2009 Mar 29.
2q35 2 rs13387042 GG 0.83 25.3% 4533 / 17513
Stacey, SN et al. Nat Genet. 2007 Jul;39(7):865-9. Epub 2007 May 27.
8q24 8 rs13281615 AG 1.01 48.0% 26048 / 25253
Easton, DF et al. Nature. 2007 Jun 28;447(7148):1087-93.
CASP8 2 rs17468277 CC 1.03 75.7% 17109 / 16423
Cox, A et al. Nat Genet. 2007 Mar;39(3):352-8. Epub 2007 Feb 11.
CDKN2A/B 9 rs1011970 GT 1.06 28.2% 12253 / 12000
Turnbull, Clare et al. Nat Genet. 2010 Jun;42(6):504-7. Epub 2010 May 9.
COX11 17 rs7222197 AG 0.98 40.3% 30256 / 34063
Ahmed, S et al. Nat Genet. 2009 Mar;41(3):324-8. Epub 2009 Feb 15.
ESR1 6 rs9383589 AA 0.98 87.8% 7899 / 11234
Stacey, Simon N et al. PLoS Genet. 2010 Jul 22;6(7):e1001029.
FGFR2 10 rs2981582 CC 0.83 38.4% 26048 / 25253
Easton, DF et al. Nature. 2007 Jun 28;447(7148):1087-93.
KLF4 / RAD23B / ACTL7A 9 rs630965 CT 0.97 47.6% 10156 / 11631
Fletcher, O et al. J Natl Cancer Inst. 2011 Mar 2;103(5):425-35. Epub 2011 Jan 24.
LSP1 11 rs3817198 TT 0.96 49.0% 26048 / 25253
Easton, DF et al. Nature. 2007 Jun 28;447(7148):1087-93.
MAP3K1 5 rs889312 AC 1.05 40.3% 26048 / 25253
Easton, DF et al. Nature. 2007 Jun 28;447(7148):1087-93.
MRPS30 5 rs4415084 CT 1.03 47.8% 4477 / 26515
Stacey, SN et al. Nat Genet. 2008 Jun;40(6):703-6. Epub 2008 Apr 27.
NEK10 3 rs4973768 CC 0.91 29.2% 30256 / 34063
Ahmed, S et al. Nat Genet. 2009 Mar;41(3):324-8. Epub 2009 Feb 15.
RAD51L1 14 rs999737 TT 0.83 5.8% 9335 / 10263
Thomas, G et al. Nat Genet. 2009 Mar 29.
TNRC9 / TOX3 16 rs3803662 TT 1.42 7.2% 4554 / 17577
Stacey, SN et al. Nat Genet. 2007 Jul;39(7):865-9. Epub 2007 May 27.
ZNF365 10 rs10995190 AG 0.90 25.5% 12261 / 12000
Turnbull, Clare et al. Nat Genet. 2010 Jun;42(6):504-7. Epub 2010 May 9.

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Chromosome location of relevant variants

The figure below shows the genomic location of the relevant variants, represented as stripes across the chromosome. Their color indicates your relative risk (red: high risk, yellow: medium risk, green: low risk). Hover over the variants with the mouse cursor to obtain more detailed information.

Bcrs

Keep in mind

These are the results of calculations comparing your genetic sequence to sequence of participants in studies published in the world literature on genetic risk for this disease. Read more about how deCODEme calculates risks.

This test was developed and its performance characteristics determined by the deCODE genetics Diagnostic Laboratory. It has not been cleared or approved by the U. S. Food and Drug Administration (FDA).